Notice: Sequencher 5.4.6 IS NOT compatible with macOS Catalina (10.15). In order to continue using Sequencher 5.4.6 please hold off on upgrading your Mac OS at this time. Gene Codes will send an email update when the new, fully compatible version is released. We understand that these unforeseen delays create new challenges for our Mac users, and we want to be proactive in providing solutions for those affected.  If you have lost access to your Sequencher license due to an upgrade to Catalina or Big Sur, please let us know, and we will work to provide a solution.